MEN1
Associated conditions:
- Endocrine cancer
- Nervous system/brain cancer
- Pancreatic cancer
MEN1 makes a protein called menin that acts as a brake on cell growth in hormone-producing glands. Genetic changes in this gene are associated with an autosomal dominant condition called multiple endocrine neoplasia type 1, driving tumours of the parathyroid glands, pancreas and pituitary. Knowing your genetic status enables regular hormone and imaging checks that catch these growths while they are small and treatable.
Conditions linked to MEN1
Endocrine cancer
Endocrine cancers affect hormone-producing glands such as the thyroid, parathyroid, adrenal glands or pancreatic islet cells. Inherited variants can drive tumours in one or more of these glands, so awareness supports periodic hormone testing and imaging to catch changes early.
Nervous system/brain cancer
Cancers of the nervous system and brain arise in the brain, spinal cord or their supporting tissues. Some inherited syndromes raise the risk of these tumours, so awareness supports prompt assessment of new neurological symptoms and, where indicated, imaging surveillance.
Pancreatic cancer
Pancreatic cancer arises in the pancreas and is often found late. Some inherited variants raise its risk, so carriers may be offered specialist surveillance (MRI or endoscopic ultrasound), which aims to catch changes at a more treatable stage.
