BRIP1
Associated conditions:
- Gynaecologic cancer
- Fanconi anaemia
BRIP1 makes a helicase enzyme that works alongside the BRCA1 protein to repair damaged DNA. Genetic changes in this gene are associated with a raised lifetime risk of ovarian cancer when one copy is altered, and, when both copies are altered, with an autosomal recessive condition called Fanconi anaemia, a distinct and more serious childhood condition. Knowing your genetic status enables preventive options like risk-reducing surgery.
Conditions linked to BRIP1
Gynaecologic cancer
Gynaecologic cancers include ovarian, uterine (endometrial) and related cancers. Inherited variants can raise the risk of one or more of these, so knowing your status guides screening discussions and risk-reducing options such as surgery after childbearing.
