Your DNA is analysed in a CLIA and CAP certified laboratory for variations in 61 genes associated with some of the most common types of cancer.
Some of the genes on the test include —
Breast, ovarian, pancreatic, prostate cancer and melanoma.
Lynch Syndrome: bowel, ovarian and uterine cancer.
Breast, colorectal, endocrine, ovarian, and prostate cancer.
|APC||Colorectal, endocrine, gastric, nervous system/brain, and pancreatic cancer, sarcoma|
|ATM||Breast, pancreatic, and prostate cancer|
|BAP1||Renal/urinary tract cancer, melanoma|
|BMPR1A||Colorectal, gastric, and pancreatic cancer|
|BRCA1||Breast, gynecologic, pancreatic, and prostate cancer|
|BRCA2||Breast, gynecologic, pancreatic, and prostate cancer, melanoma|
|BRIP1||Breast and gynecologic cancer|
|CDC73||Endocrine and renal/urinary tract cancer|
|CDH1||Breast, colorectal, and gastric cancer|
|CDKN2A||Nervous system/brain and pancreatic cancer, melanoma|
|CHEK2||Breast, colorectal, endocrine, gynecologic, and prostate cancer|
|DICER1||Endocrine, gynecologic, nervous system/brain, and renal/urinary tract cancer, sarcoma|
|EPCAM||Colorectal, gastric, gynecologic, nervous system/ brain, pancreatic, prostate, and renal/urinary tract cancer|
|FH||Renal/urinary tract cancer, sarcoma|
|FLCN||Renal/urinary tract cancer|
|KIT||Gastric cancer, sarcoma|
|MEN1||Endocrine, nervous system/brain, and pancreatic cancer|
|MET||Renal/urinary tract cancer|
|MLH1||Colorectal, gastric, gynecologic, nervous system/ brain, pancreatic, prostate, and renal/urinary tract cancer|
|MSH2||Colorectal, gastric, gynecologic, nervous system/ brain, pancreatic, prostate, and renal/urinary tract cancer|
|MSH3||Colorectal cancer, includes reporting of carrier status|
|NBN||Breast and prostate cancer|
|NF1||Breast, endocrine, gastric, and nervous system/brain cancer|
|NF2||Nervous system/brain cancer|
|NTHL1||Colorectal cancer, includes reporting of carrier status|
|PALB2||Breast and pancreatic cancer|
|PDGFRA||Gastric cancer, sarcoma|
|PRKAR1A||Endocrine and nervous system/brain cancer, sarcoma|
|PTCH1||Nervous system/brain and skin cancer, sarcoma|
|PTEN||Breast, colorectal, endocrine, gynecologic, nervous system/brain and, renal/urinary tract cancer, melanoma|
|RAD51C||Breast and gynecologic cancer|
|RAD51D||Breast and gynecologic cancer|
|RB1||Melanoma, retinoblastoma, sarcoma|
|SDHA||Endocrine and gastric cancer, sarcoma|
|SDHB||Endocrine, gastric, and renal/urinary tract cancer, sarcoma|
|SDHC||Endocrine, gastric, and renal/urinary tract cancer, sarcoma|
|SDHD||Endocrine, gastric, and renal/urinary tract cancer, sarcoma|
|SMAD4||Colorectal, gastric, and pancreatic cancer|
|SMARCB1||Nervous system/brain and renal/urinary tract cancer|
|STK11||Breast, colorectal, gastric, gynecologic, and pancreatic cancer|
|TP53||Breast, endocrine, gastrointestinal, genitourinary, gynecologic, hematologic, nervous system/brain, and skin cancer, sarcoma|
|TSC1||Nervous system/brain, pancreatic, and renal/urinary tract cancer|
|TSC2||Nervous system/brain, pancreatic, and renal/urinary tract cancer|
|VHL||Endocrine, nervous system/brain, pancreatic, and renal/urinary tract cancer|
|WT1||Renal/urinary tract cancer|
What is genetic counselling?+
Genetic counsellors guide people in making important decisions around how genetics influences their health. They are not doctors, but are genetic specialists that are trained to identify, explore and explain genetic risk. They can help you be practically and emotionally prepared to make empowered choices that feel right for you.
At no additional cost, connect with your Eugene genetic counsellor to discuss your test results. They can help you understand your results, answer any questions and help you learn more about what your results mean for you.
If a gene variation is found that increases my risk, does that mean I will develop cancer?+
No. Genetics is only one part of the cancer risk puzzle. Having a gene variant in one of the genes included on our test will increase your chance of developing cancer, but not everyone who has a gene variation will get cancer in their lifetime.
There are many other factors that contribute to your risk, including environmental factors like exposure to the sun and lifestyle factors like smoking and exercise. If a gene variant is identified on our test, your results will include information about the specific gene variation you carry and how it influences your cancer risk so you can better understand your lifetime chance of developing that specific type cancer.
Could this test affect my ability to get insurance?+
In some cases this test could impact your ability to get life or income protection insurance.
Could have an impact —
How are my results used by my doctor in my ongoing care?+
Your result will help you and your doctor determine any action strategies for prevention and early detection that might be appropriate for you.
You can learn more about that here.
How can I share results with my doctor?+
Eugene's proactive cancer risk test includes a personal clinical report that will have details about your results, that you can share with your doctor. The clinical report is available for you when you receive your results.
You can also speak with a Eugene genetic counsellor at no additional charge. Genetic counsellors can help you understand your results, consider next steps, and discuss how to share information with doctors and family.
What's the turnaround time?+
From the moment we receive your saliva sample, the turnaround time to get your results is 3 to 4 weeks.
Is there support to help me understand my results?+
Absolutely! Each test comes with a post test genetic counselling session. Your Eugene genetic counsellors are all trained and have practiced across a number of specialties in addition to carrier screening and together with our consultant geneticists and widespread network of healthcare professionals, we make sure you're always connected and supported.
Are my results and personal info protected?+
As a healthcare company, we comply with the most stringent local and international privacy and security regulations. We take incredible care to use technical, process and physical safeguards to secure your personal information and protect it against misuse, loss or alteration.
Finally, Eugene doesn't share any your data with anyone but you and (with your express permission) your doctor.
I don't have a family history of cancer, is this still relevant for me?+
Yes. Even if you don't have a family history you could still have a genetic risk that increases your own risk. Not everyone who carries an increased risk gene variant will develop cancer, so not every family will have a cancer history. So, while gene variations that increase cancer risk are rare, knowing whether or not there's one in you or your family could be lifesaving.
What happens to my sample once the test is complete?+
Your saliva sample is destroyed after 60 days. In unusual cases when testing takes longer than 30 days, the specimen will be retained until the report is delivered.